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  • Title: Substance P-immunoreactive processes on 5HT/SP-immunoreactive medullary cells.
    Author: Hancock MB.
    Journal: Brain Res Bull; 1984 Oct; 13(4):559-63. PubMed ID: 6084543.
    Abstract:
    Two-color immunoperoxidase staining has been used to localize substance P (SP)-immunoreactive processes on neurons in the caudal medulla that exhibited both serotonin (5HT)- and SP-immunoreactivity (5HTI/SPI cells). The punctate SP-immunoreactive processes were present on 5HTI/SPI cells in the raphe nuclei and ventral reticular formation. This close association suggests that activity in bulbospinal 5HT/SP pathways, which can influence sympathetic preganglionic neurons, may be affected by the release of SP in the brainstem.
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