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  • Title: Vascular relaxation by ifenprodil in the isolated perfused rat mesenteric artery.
    Author: Adeagbo AS.
    Journal: J Cardiovasc Pharmacol; 1984; 6(6):1142-7. PubMed ID: 6084772.
    Abstract:
    The possible mechanism of vascular relaxation by ifenprodil has been examined in the isolated perfused rat mesenteric artery preparation. Ifenprodil (5.0 X 10(-9)-5.0 X 10(-8) M) noncompetitively blocked noradrenaline- and cirazoline-induced vasoconstrictor responses. This concentration range did not affect responses to 5-hydroxytryptamine and potassium chloride. However, in concentrations above 10(-6) M, ifenprodil caused (a) reversal of constrictor responses to excess potassium given either by bolus injections (3.4 X 10(-2)-5.4 X 10(-1) M) or by continuous perfusion (55 mM) and (b) inhibition of Ca2+-induced constrictor effects in arteries perfused with Ca2+-free depolarizing Krebs solution. It is concluded that ifenprodil blocks Ca2+ mobilization through both the ion channels coupled to alpha-adrenoceptors and the potential-sensitive channels.
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