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  • Title: [Protein-synthesizing apparatus of the rat liver and placenta during damage of the biomembrane by tetrachloromethane and the administration of methylxanthines].
    Author: Gubskiĭ IuI, Radzinskiĭ VE, Smal'ko PIa, Korniushina TV.
    Journal: Vopr Med Khim; 1984; 30(6):57-61. PubMed ID: 6084894.
    Abstract:
    Treatment of rats with tetrachloromethane was accompanied by a decrease in total ribosomal material, an increase in free, unbound with membranes, polyribosomal fraction and marked decrease in 14C-leucine and 3H-orotate incorporation into proteins and RNA of liver and placenta cells. Administration of methylxanthines--euphylline and trental protected the protein-synthesizing apparatus of hepatocytes and placenta from the damaging effects of tetrachloromethane. The role of microsomal monooxygenase system in tetrachloromethane activation and in impairment of cAMP-dependent regulation of translation process under conditions of xenobiotic-induced cell injury are discussed.
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