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  • Title: [Heterogeneity of monospecific antibodies to the hemagglutinin of influenza virus H3N2 studied by radioimmunological analysis].
    Author: Blokha VV, Iamnikova SS, Karpovich LG, Iakhno MA, Zakstel'skaia LIa.
    Journal: Vopr Virusol; 1984; 29(6):672-5. PubMed ID: 6084896.
    Abstract:
    Heterogeneity of antibodies against influenza virus hemagglutinin has been confirmed. Various subpopulations of antibodies to the A/Khabarovsk/15/76 hemagglutinin were demonstrated some of which showed greater affinity to MRC-11 hemagglutinin than to the HA of the strain inducing this antibody synthesis. Apparently subpopulations of antibodies with low affinity to their "own" epitopes in the hemagglutinin-immunogen may develop which, however, may show a sufficiently high affinity to these epitopes in hemagglutinins of other strains.
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