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  • Title: [Detection of the virus-specific antigens of adenoviruses and herpes simplex virus in patients with malignant genital diseases].
    Author: Posevaia TA, Kulcsar G, Horváth I, Dan P, Nasz I.
    Journal: Vopr Virusol; 1984; 29(6):727-30. PubMed ID: 6084901.
    Abstract:
    The possibility of detecting virus-specific antigens in women with various pathological changes of the genitalia (cancer and pre-cancer conditions) was demonstrated. Comparative examinations of specimens from patients with cancer diseases of the genitalia for the presence of structural and virus-induced early antigens of HSV-2 demonstrated immunofluorescence test (IFT) to be the diagnostic test for the detection of HSV antigens in patients with cervical carcinoma. The rate of virus-induced antigen findings in the group of patients with cervical carcinoma was 51.6%, in precancer conditions, 31.7%, in recurrent genital herpes, 78.5%, in the control group of healthy women, 5%, by the IFT. The detection of virus-specific adenovirus and herpes antigens in human tumors is of interest for further investigation of a possible role of these viruses in the generation of malignant neoplasias and for the development of methods for specific immunodiagnosis.
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