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  • Title: Phenotypic characterization in situ of inflammatory cells in pityriasis (tinea) versicolor.
    Author: Scheynius A, Faergemann J, Forsum U, Sjöberg O.
    Journal: Acta Derm Venereol; 1984; 64(6):473-9. PubMed ID: 6084917.
    Abstract:
    The cellular response in pityriasis (tinea) versicolor lesions was analysed in situ with an immunohistochemical double staining technique combined with periodic acid-Schiff staining in frozen sections of skin biopsies from 9 patients. The proportions of B and T cells and subpopulations of T cells in the blood were normal as were the proliferative responses of blood mononuclear cells against various B- and T-cell mitogens and antigens. Fungi were observed in stratum corneum in all lesions, and there were moderate cell infiltrates in both epidermis and dermis as compared to biopsies from normal-looking skin. The majority of the infiltrating perivascular cells reacted with anti-Leu 1 antibodies (all mature peripheral T cells). Anti-Leu 2a reactive cells ('suppressor/cytotoxic' phenotype) were few and scattered, whereas anti-Leu 3a reactive cells ('helper/inducer' phenotype) dominated. This investigation demonstrates that pityriasis versicolor is not a simple overgrowth of the fungus in stratum corneum, but is accompanied by infiltrating immunocompetent cells in both epidermis and dermis.
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