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  • Title: The urinary excretion of 5-hydroxyindoleacetic acid does not reflect brain levels of this metabolite of 5-hydroxytryptamine.
    Author: Aizenstein ML, Scavone C.
    Journal: Braz J Med Biol Res; 1984; 17(3-4):323-7. PubMed ID: 6085023.
    Abstract:
    The present study was undertaken to determine if changes in the serotonergic central nervous system can be reflected by urinary 5-hydroxyindoleacetic acid (5-HIAA) levels. Cerebral, spinal and urinary levels of 5-HIAA were determined and compared in rats whose cerebral 5-HIAA concentration had been depleted by nucleus raphe dorsalis and medialis lesion or increased by L-tryptophan loading. Since no differences were observed in the urinary excretion of 5-HIAA we conclude that this parameter cannot be used to detect changes in the serotonergic central nervous system.
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