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  • Title: Effect of sodium saccharin on rat pancreatic enzyme secretion.
    Author: Kondoh M, Ohe M, Ono A, Hagihira H.
    Journal: J Nutr Sci Vitaminol (Tokyo); 1984 Dec; 30(6):569-76. PubMed ID: 6085346.
    Abstract:
    Intragastric administration of casein, oleic acid, or polyvinylpyrrolidone resulted in a marked increase in the pancreatic secretion of enzymes, and the administration of 0.03% sodium saccharin, at the concentration permitted in soft drinks, inhibited this increase with these substances. The stimulation of secretion of pancreatic juice-bile mixture by these substances was also inhibited by administration of sodium saccharin. Intravenous injection of CCK-PZ (cholecystokinin-pancreozymin) during inhibition by sodium saccharin, caused a rapid increase in amylase output, suggesting that sodium saccharin acts on the site(s) of CCK-PZ release to prevent its secretion even in the presence of a stimulant, but does not reduce the sensitivity of the pancreas to CCK-PZ. Sodium saccharin seemed to have an effect on secretin release similar to that on CCK-PZ release, judging from the results for the volume of juice-bile mixture.
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