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  • Title: Effect of interferons on dengue virus multiplication in cultured monocytes/macrophages.
    Author: Hotta H, Hotta S, Homma M.
    Journal: Biken J; 1984 Dec; 27(4):189-93. PubMed ID: 6085674.
    Abstract:
    The effects of interferons on dengue virus multiplication in cultured human and mouse monocytes/macrophages were studied. Interferon treatment before, but not after virus inoculation suppressed virus multiplication dose-dependently. Recombinant human leukocyte A interferon was as effective as ordinary human fibroblast interferon in suppressing dengue virus multiplication in cultured human monocytes. Human monocytes, a population of non-proliferating cell lineage, maintained their interferon-mediated antiviral state for a few days after removal of the interferons.
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