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  • Title: Activity of beta-lactamase inhibitors in combination with new beta-lactam antibiotics against resistant gram-negative organisms.
    Author: Bolivar R, Weaver SS, Bodey GP.
    Journal: Diagn Microbiol Infect Dis; 1984 Jun; 2(3):255-60. PubMed ID: 6086213.
    Abstract:
    Thirty-eight isolates of gram-negative bacilli resistant to four new beta-lactam antibiotics, aztreonam, moxalactam, ceftazidime, and cefoperazone, were tested in the presence of two beta-lactam inhibitors, clavulanic acid and sulbactam. Microorganisms tested included 22 isolates of Pseudomonas species, 5 of Klebsiella species, and 11 of Enterobacter species. A 2- to 10-fold decrease in minimum inhibitory concentration was noted when antibiotics and beta-lactamase inhibitors were combined compared to antibiotics alone. Four strains of Pseudomonas aeruginosa showed increased resistance to the combination of antibiotics and beta-lactamase inhibitors.
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