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  • Title: Repression by dexamethasone of epinephrine-induced modulation of the fatty acyl-CoA desaturase system in Tetrahymena microsomes.
    Author: Umeki S, Nozawa Y.
    Journal: Eur J Biochem; 1984 Jul 16; 142(2):355-9. PubMed ID: 6086351.
    Abstract:
    Epinephrine modulation of the fatty acyl-CoA desaturase activities in Tetrahymena microsomes, namely the stimulation of delta 9 desaturase activity with a decreased activity of delta 12 desaturase, was markedly inhibited by dexamethasone administered 30 min prior to epinephrine addition. This effect by dexamethasone was dose-dependent. With epinephrine or dexamethasone prior to epinephrine administration, the activities of delta 9-terminal and delta 12-terminal components were found to change in parallel with those of delta 9 and delta 12 desaturase activities respectively. Furthermore, addition of dexamethasone as early as 30 min before epinephrine repressed the epinephrine-mediated stimulation of cyclic AMP production and of adenylate cyclase activity. Therefore, it is suggested that dexamethasone may inhibit the modulation by epinephrine of the terminal component activity, which plays a crucial role in microsomal fatty acyl-CoA desaturase system, through the reduction of cyclic AMP accumulation by decreased responsiveness to epinephrine of Tetrahymena cells.
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