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  • Title: Decreased platelet 3H-imipramine binding sites in classical migraine.
    Author: Geaney DP, Rutterford MG, Elliott JM, Schächter M, Peet KM, Grahame-Smith DG.
    Journal: J Neurol Neurosurg Psychiatry; 1984 Jul; 47(7):720-3. PubMed ID: 6086845.
    Abstract:
    Patients with classical migraine investigated between attacks had significantly fewer platelet 3H-imipramine binding sites than control subjects and this finding was more marked in males than in females. There was no abnormality of binding characteristics of platelet 5-hydroxytryptamine receptors or of platelet alpha 2-adrenoceptors. Because the reduced 3H-imipramine binding capacity was found in classical migraineurs who were investigated between attacks, it may reflect a predisposition to migraine rather than being a consequence of attacks.
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