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  • Title: Fertilization increases the polyphosphoinositide content of sea urchin eggs.
    Author: Turner PR, Sheetz MP, Jaffe LA.
    Journal: Nature; ; 310(5976):414-5. PubMed ID: 6087155.
    Abstract:
    Fertilization of the sea urchin egg stimulates a wave of exocytosis of cortical vesicles, but the mechanism by which fertilization regulates this secretion is not fully understood. We describe here experiments which suggest that polyphosphoinositide metabolism could be a factor in this regulation. We find that the cortical vesicle exocytosis in the egg of Strongylocentrotus purpuratus is preceded by a 40% increase in its content of triphosphoinositide (TPI) and a 22% increase of diphosphoinositide (DPI).
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