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Title: [Evaluation of the extravascular distribution of cefotiam (SCE 963) by the skin blister technic]. Author: Bryskier A, Elbaz P, Fourtillan JB, Ortonne JP. Journal: Pathol Biol (Paris); 1984 Jun; 32(5 Pt 2):506-8. PubMed ID: 6087248. Abstract: Extravascular diffusion of cefotiam was studied by a suction blister technique. Maximal cefotiam concentration in blister fluid (18.4 +/- 6.4 micrograms X ml-1) was found one hour after intravenous injection of a 1 g bolus. The area under the curve (AUC) of blister fluid concentrations was 35.4 micrograms X ml-1. Apparent elimination half-life from blister fluid was 0.72 hour. The AUC plasma/AUC blister fluid ratio approximated 1.[Abstract] [Full Text] [Related] [New Search]