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  • Title: [Biological activity of transition metal complexes. 5. Effect of dimethyl sulfoxide on the cytotoxic, antiviral and antitumoral properties of cis-dichlorodiammineplatinum (II): "cisplatin"].
    Author: Tonew M, Tonew E, Gutsche W, Wohlrabe K, Stelzner A, Schröer HP, Heyn B.
    Journal: Zentralbl Bakteriol Mikrobiol Hyg A; 1984 May; 257(1):108-20. PubMed ID: 6087577.
    Abstract:
    In water or dimethyl sulfoxide solutions cis-platinum is subject of time depending solvolytic reactions leading to compounds with different biological effectivity. Whereas the inactivation of vaccinia, vesicular stomatitis and adeno virus type 5 was not changed if dimethyl sulfoxide or dimethyl formamide instead of destilled water were used as solvents, long time stored solutions of cis-platinum in dimethyl sulfoxide were tolerated by cells cultivated in vitro in 8-25 times higher concentrations in comparison with a freshly solved preparation. Their antiviral effectivity was maintained. On the other hand experiments with mice showed that simultaneously with the decrease of toxicity of an aged cis-platinum solution in DMSO also its antileukemic activity disappeared. In a 5 weeks old cis-platinum solution in destilled water antitumor activity was preserved in spite of enhanced toxicity.
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