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  • Title: The localization of the gene for apolipoprotein C-II to chromosome 19.
    Author: Fojo SS, Law SW, Brewer HB, Sakaguchi AY, Naylor SL.
    Journal: Biochem Biophys Res Commun; 1984 Jul 31; 122(2):687-93. PubMed ID: 6087809.
    Abstract:
    Human apolipoprotein (apo) C-II, a 79 amino acid protein, functions as a cofactor for lipoprotein lipase, the enzyme which catalyzes the hydrolysis of plasma triglycerides. The chromosomal location of apoC-II has been determined by filter hybridization analysis of human-mouse hybrid cells. Southern blots of DNA from 21 human-mouse hybrid cells were hybridized with a 190 base pair nick translated probe prepared from a Hinf I digest of an apoC-II cDNA clone. Without exception, ApoC-II segregated with chromosome 19 thus establishing synteny with the apoE and LDL receptor genes known to be localized to this chromosome. The localization of the apoC-II gene to chromosome 19 will permit more detailed analysis of the genomic organization and linkages of the apolipoprotein genes.
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