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  • Title: Protein-mediated intermembrane contact facilitates fusion of lipid vesicles with planar bilayers.
    Author: Young TM, Young JD.
    Journal: Biochim Biophys Acta; 1984 Sep 05; 775(3):441-5. PubMed ID: 6087909.
    Abstract:
    Fusion of phospholipid vesicles with planar bilayer membranes occurs provided there is an intermembrane contact, which can be mediated by phospholipid-binding proteins, even in the absence of calcium. The firm attachment phase is then followed by the osmotically-driven fusion. These results show that hydrophobic proteins (not necessarily Ca2+-binding proteins) may enhance fusion by promoting contact of membranes. Such proteins may operate synergistically with Ca2+ to reduce the threshold concentration of Ca2+ needed for fusion of biological membranes. Protein-mediated intermembrane contact resulting in fusion may play a crucial role in the regulation and catalysis of biological fusion events.
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