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  • Title: [Regulation of purified NAD-isocitrate dehydrogenase from the pig heart by calcium ions and cAMP-dependent protein kinase].
    Author: Kulinskiĭ VI, Kolpakova TV.
    Journal: Biull Eksp Biol Med; 1984 Aug; 98(8):188-90. PubMed ID: 6087956.
    Abstract:
    Different cAMP-dependent protein kinases do not phosphorylate homogeneous NAD-isocitrate dehydrogenase (ICDH) and do not change its activity. Ca2+ (3 X 10(-7) = 10(-3) M) activates the enzyme throughout the process of purification including homogeneous enzyme by decreasing the KM for isocitrate. The calmodulin inhibitor trifluoperazine does not change ICDH activation.
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