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  • Title: Activated oxygen and mammalian nitrate biosynthesis.
    Author: Dull BJ, Hotchkiss JH.
    Journal: Carcinogenesis; 1984 Sep; 5(9):1161-4. PubMed ID: 6088104.
    Abstract:
    The oxidation of NH3 to NO3- by rat liver in vitro is described. A xanthine-xanthine oxidase reaction also oxidized NH3 to NO3- when H2O2 was added. An in vivo inhibitor of superoxide dismutase enhanced the in vitro liver conversion of NH3 to NO3-. Thus, intracellular oxidation by activated oxygen likely represents the source of endogenously formed NO3- in mammals.
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