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  • Title: Chemotactic factor-induced enhancement of the binding of human immunoglobulin classes and subclasses to neutrophils and eosinophils.
    Author: Kay AB, Walsh GM.
    Journal: Clin Exp Immunol; 1984 Sep; 57(3):729-34. PubMed ID: 6088141.
    Abstract:
    Sheep erythrocytes (E) coated with either human IgG1, IgG2, IgG3 or IgG4 myeloma proteins formed rosettes with human neutrophils and eosinophils. Prior incubation with the chemotactic agents f-met-leu-phe or leukotriene B4 enhanced neutrophil and eosinophil E-IgG1 rosettes in a time- and dose-dependent fashion. There were comparable increases in neutrophil and eosinophil f-met-leu-phe-induced rosettes with either E-IgG1, E-IgG2, E-IgG3 or E-IgG4 whereas this agent did not appear to influence E-IgA1, E-IgD, E-IgM or E-IgE binding to these granulocytes. These studies indicate that human neutrophil and eosinophil IgG (Fc) receptors are enhanced by chemotactic agents in a similar way to that previously described for complement receptors.
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