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  • Title: Sequence requirements for nuclear location of simian virus 40 large-T antigen.
    Author: Kalderon D, Richardson WD, Markham AF, Smith AE.
    Journal: Nature; ; 311(5981):33-8. PubMed ID: 6088992.
    Abstract:
    A point mutation in the simian virus 40 large-T gene, which was generated by mixed oligonucleotide mutagenesis and resulted in the conversion of Lys 128 to Thr, produced a large-T antigen that was detected in the cytoplasm but not the nucleus of cells. Deletions within the surrounding sequence Lys-128Lys-Lys-Arg-Lys-Val-Glu also produce cytoplasmic large-T and define a region of the protein involved in nuclear location.
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