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  • Title: Alternative RNA processing: determining neuronal phenotype.
    Author: Rosenfeld MG, Amara SG, Evans RM.
    Journal: Science; 1984 Sep 21; 225(4668):1315-20. PubMed ID: 6089345.
    Abstract:
    On the basis of an analysis of the human and rat calcitonin genes and of a related gene, alternative RNA processing represents a developmental strategy of the brain to dictate tissue-specific patterns of polypeptide synthesis. This regulation allows the calcitonin gene to generate two messenger RNA's, one encoding the precursor of a novel neuropeptide, referred to as CGRP, which predominates in the brain, and the second encoding the precursor to the hormone calcitonin which predominates in thyroid C cells. The distribution of CGRP in the central and peripheral nervous system and in endocrine and other organ systems suggests potential functions in nociception, ingestive behavior, cardiovascular homeostasis, and mineral metabolism.
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