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  • Title: The genes coding for A alpha-, B beta-, and gamma-chains of fibrinogen map to 4q2.
    Author: Henry I, Uzan G, Weil D, Nicolas H, Kaplan JC, Marguerie C, Kahn A, Junien C.
    Journal: Am J Hum Genet; 1984 Jul; 36(4):760-8. PubMed ID: 6089549.
    Abstract:
    We used cloned cDNA probes for the A alpha-, B beta-, and gamma-chains of human fibrinogen and Southern blotting techniques to analyze DNA from a series of rodent X human somatic cell hybrids for the presence of specific fibrinogen-related sequences. Our results provide evidence for the assignment of the three genes for fibrinogen to chromosome 4. Moreover, by direct gene-dosage determination in two patients with chromosome 4 unbalanced rearrangements, we refined the regional chromosomal assignment to 4q2, thus suggesting that these three genes whose expression is coordinately regulated are closely linked.
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