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  • Title: Increase in rat cortical [3H]naloxone binding site density after chronic administration of antidepressant agents.
    Author: Antkiewicz-Michaluk L, Rokosz-Pelc A, Vetulani J.
    Journal: Eur J Pharmacol; 1984 Jun 15; 102(1):179-81. PubMed ID: 6090155.
    Abstract:
    Given chronically, the first and second generation antidepressants imipramine and citalopram, and antidepressant neuroleptics levomepromazine and chlorprothixene, elevated moderately but significantly (by 15-30%) the density of [3H]naloxone binding sites in rat cerebral cortical membranes. There were only small non-significant changes in Kd values.
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