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  • Title: Functional size of the human asialoglycoprotein receptor as determined by radiation inactivation.
    Author: Schwartz AL, Steer CJ, Kempner ES.
    Journal: J Biol Chem; 1984 Oct 10; 259(19):12025-9. PubMed ID: 6090451.
    Abstract:
    The radiation target size of the functional asialoglycoprotein receptor (ASGP-R) in purified plasma membranes was determined for human liver and the human hepatoma cell line, Hep G2, by evaluation of the binding of 125I-asialoorosomucoid. Identical inactivation curves were observed for ASGP-R from normal human liver and post-mortem human liver and exhibited a functional unit of 70,000 daltons. The human hepatoma Hep G2 ASGP-R, in contrast, showed a target size of 140,000 daltons. These results suggest that the functional ligand-binding unit of the human ASGP-R is a multimer of the approximately 34,000-dalton unglycosylated receptor polypeptide (Schwartz, A. L., and Rup, D. (1983) J. Biol. Chem. 258, 11249-11255).
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