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  • Title: Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III.
    Author: Mitsuya H, Popovic M, Yarchoan R, Matsushita S, Gallo RC, Broder S.
    Journal: Science; 1984 Oct 12; 226(4671):172-4. PubMed ID: 6091268.
    Abstract:
    A recently discovered member of the human T-cell leukemia virus (HTLV) family of retroviruses has been etiologically linked to the acquired immune deficiency syndrome (AIDS). This virus, which has been designated HTLV-III, is tropic for OKT4-bearing (helper-inducer) T cells. Moreover, the virus is cytopathic for these cells. Suramin is a drug used in the therapy of Rhodesian trypanosomiasis and onchocerciasis, and it is known to inhibit the reverse transcriptase of a number of retroviruses. Suramin has now been found to block in vitro the infectivity and cytopathic effect of HTLV-III at doses that are clinically attainable in human beings.
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