These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Site-specific antibodies to the erbB oncogene product immunoprecipitate epidermal growth factor receptor.
    Author: Akiyama T, Yamada Y, Ogawara H, Richert N, Pastan I, Yamamoto T, Kasuga M.
    Journal: Biochem Biophys Res Commun; 1984 Sep 17; 123(2):797-802. PubMed ID: 6091642.
    Abstract:
    Antiserum to a defined region (residues 373-383) of the erbB oncogene product immunoprecipitated a 170,000 dalton protein that was phosphorylated in an EGF-sensitive fashion as well as the 125I-EGF-receptor complex from A431 human epidermoid carcinoma cells. Preincubation of the antiserum with an excess of the synthetic peptide corresponding to the defined region blocked the immunoprecipitation of this protein. A partial proteolytic peptide map of this immunoprecipitated 170,000 dalton protein was identical to that of the authentic EGF receptor. These results suggest immunological similarity between the erbB gene product and the EGF receptor.
    [Abstract] [Full Text] [Related] [New Search]