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  • Title: Changes in cytosolic free Ca2+ in isolated parietal cells. Differential effects of secretagogues.
    Author: Muallem S, Sachs G.
    Journal: Biochim Biophys Acta; 1984 Oct 12; 805(2):181-5. PubMed ID: 6091776.
    Abstract:
    The relationship of free cytosolic Ca2+ to secretagogue-dependent activation of acid secretion by the mammalian parietal cell was studied using quin 2 as an intracellular Ca2+ probe. The resting [Ca2+]in of isolated dog parietal cells was found to be 134 +/- 11 nM. Carbachol produced a steady-state increase of [Ca2+]in and its effect was blocked by atropine and Ca2+ -channel blocking agents. Gastrin transiently elevated [Ca2+]in and this was not affected by Ca2+ -channel blocking agents. Neither histamine nor dbcAMP changed resting [Ca2+]in in rabbit parietal cells.
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