These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Assessment of sodium-potassium ATPase activity in human erythrocytes in vitro.
    Author: Lijnen P, Groeseneken D, Laermans M, Lommelen L, Piccart Y, Amery A.
    Journal: Methods Find Exp Clin Pharmacol; 1984 Aug; 6(8):417-21. PubMed ID: 6092796.
    Abstract:
    The red cell Na+,K+-ATPase pump activity was measured either by the ouabain-sensitive 86Rb-uptake in the presence or absence of 4 mM potassium in the external medium or by the ouabain-sensitive Na+-efflux in normal male subjects without any medication (n = 14) and during short-term treatment with the serotonin-antagonist, ketanserin. The ouabain-sensitive 86Rb-uptake in a medium containing 4 mM K+ was related to the 86Rb-uptake in a K+-free medium (r = 0.82; p less than 0.001) and to the Na+ efflux (r = 0.74; p less than 0.01). The intra-erythrocyte sodium concentration was negatively related to the ouabain-sensitive 86Rb-uptake (K+-free medium r = 0.59, p less than 0.05: 4 mM K+ in medium r = -0.85; p less than 0.01) and to the ouabain-sensitive Na+ efflux (r = -0.53; p less than 0.05). During serotonin antagonism with ketanserin no changes were found in the ouabain-sensitive 86Rb-uptake or Na+-efflux.
    [Abstract] [Full Text] [Related] [New Search]