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  • Title: DNA amplification and an unstable arginine gene in Streptomyces lividans 66.
    Author: Altenbuchner J, Cullum J.
    Journal: Mol Gen Genet; 1984; 195(1-2):134-8. PubMed ID: 6092842.
    Abstract:
    Streptomyces lividans 66 produced spontaneous chloramphenicol-sensitive mutants (CmlS) at a frequency of about 1% of spores. The CmlS mutant strains were very unstable, giving Arg- mutants at frequencies of about 25% of spores. All the Arg- mutants had amplified a particular 5.75 kb DNA fragment into tandem repeats of 250-500 copies per chromosome.
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