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  • Title: Nicotinic transmission in sympathetic ganglia: blockade by the snake venom neurotoxin kappa-bungarotoxin.
    Author: Chiappinelli VA, Dryer SE.
    Journal: Neurosci Lett; 1984 Sep 07; 50(1-3):239-44. PubMed ID: 6093012.
    Abstract:
    Kappa-bungarotoxin, a snake venom alpha-neurotoxin, blocks nicotinic transmission in chick lumbar sympathetic ganglia as well as in the rat superior cervical ganglion. Intracellular and extracellular recordings support the conclusion that the toxin has a specific action at the postsynaptic nicotinic receptors on ganglia neurons. The affinity of kappa-bungarotoxin for receptors in chick ganglia appears to be higher than that for receptors in the rat ganglia. Kappa-bungarotoxin can thus be used as a ligand for studying nicotinic receptors in a variety of neuronal preparations.
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