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  • Title: Detection and characterization of simian retroviruses homologous to human T-cell leukemia virus type I.
    Author: Komuro A, Watanabe T, Miyoshi I, Hayami M, Tsujimoto H, Seiki M, Yoshida M.
    Journal: Virology; 1984 Oct 30; 138(2):373-8. PubMed ID: 6093374.
    Abstract:
    Lymphoid cell lines were established from five different species of monkeys which were positive in antibodies cross-reactive with human T-cell leukemia virus type I (HTLV-I) and were shown to contain provirus sequences homologous to HTLV-I. Gene-specific probes of HTLV-I, gag, pol, env, pX, and LTR, hybridized efficiently with monkey DNAs from these cell lines under stringent conditions, indicating that the proviruses are very similar to HTLV-I along with whole viral genomes. However, the preliminary restriction mapping turned out the difference between simian retroviruses and HTLV-I and also among simian retroviruses. These findings suggest a common ancestor of simian and human retroviruses, but exclude the recent interspecies transmission between monkeys and humans.
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