These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Influence of experimentally induced cholestasis on the pharmacokinetics of cefotiam.
    Author: Alonso IG, Mariño EL, Dominguez-Gil A.
    Journal: Arzneimittelforschung; 1984; 34(7):798-800. PubMed ID: 6093824.
    Abstract:
    The pharmacokinetics of (7 beta-[2-(2-amino-thiazol-4-yl) acetamido]-3-[[1-(2-dimethylaminoethyl)-1H-tetrazol- 5-yl]thio)methyl)-ceph-3-em-4-carboxylic acid (cefotiam) was studied in rabbits with normal and experimentally decreased or annulled biliary excretion. The latter two states were induced by administration of 17 beta-estradiol and by tying of the choledochus, respectively. All animals included in the study received a single i.v. bolus type injection of 40 mg/kg of the antibiotic. The average values of the pharmacokinetic parameters obtained after such administration to the control rabbits, with normal biliary excretion, expressed in accordance with a two-compartment open kinetic model were: alpha = 15.598 h-1; beta = 2.717 h-1; K12 = 5.247 h-1; K21 = 7.093 h-1 and K13 = 5.975 h-1. Cholestasis modifies the parameters defining the distribution and elimination of cefotiam to a considerable extent. The serum half-life of the slow elimination phase had an average value of 0.116 h in the control group and 0.207 h in the group with mechanically induced cholestasis. Chemically induced cholestasis caused a lesser increase in the serum half-life.
    [Abstract] [Full Text] [Related] [New Search]