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  • Title: ATPase activity of erythrocyte membrane in patients with trisomy 21 (Down's syndrome).
    Author: Xue QM, Shen DG, Dong W.
    Journal: Clin Genet; 1984 Nov; 26(5):429-32. PubMed ID: 6094054.
    Abstract:
    ATPase activity of crythroyte membranes was determined in 25 cases of Down's syndrome verified by cytological and psychological examinations. The age range of the patients was 8-25 years; 16 males and 9 females. Thirty health male volunteers were selected as the control group. There was a marked reduction of total ATPase, Na+, K+-ATPase, Mg++ATPase activities and rate of ouabain inhibition in the patients with Down's syndrome. The authors suggest that there might exist transport defects in the red cell membranes in such patients.
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