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  • Title: [Correlation of presynaptic components (uptake--release) in antidepressants].
    Author: Dolzhenko AT.
    Journal: Farmakol Toksikol; 1984; 47(5):22-5. PubMed ID: 6094236.
    Abstract:
    Experiments on the rat brain slices were made to study the relationship between the ability of 19 antidepressants to inhibit the reverse monoamine uptake (14C-noradrenaline, 3H-serotonin, 3H-dopamine) and that to enhance their presynaptic release. Antidepressants were demonstrated to have the dual nature of the presynaptic mechanism of the aminopotentiating action, which is determined by the inhibitory effect on the uptake and stimulating action on impulse release of monoamines. It was found that imipramine-like and bicyclic antidepressants have two components of presynaptic activity, whereas iprindole, noveril, peptides, and beta-carbolines are marked by the predominant effect on impulse release of monoamines. Chlorimipramine had an identical effect on the uptake and release of all three amines. Antidepressants belonging to the LU series affected mainly serotonin, whereas desipramine and nortriptyline mainly the noradrenaline uptake and release.
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