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  • Title: Diffusion of ceftriaxone into the cerebrospinal fluid of adults.
    Author: Chandrasekar PH, Rolston KV, Smith BR, LeFrock JL.
    Journal: J Antimicrob Chemother; 1984 Oct; 14(4):427-30. PubMed ID: 6094424.
    Abstract:
    Fourteen adults, three recovering from bacterial meningitis, were given a single 2 g dose of ceftriaxone or three 2 g doses at 12-hourly intervals. The mean per cent penetration of drug into cerebrospinal fluid (CSF) across uninflamed meninges was 1.5%. These levels, although low, are bactericidal in vitro against most pathogens causing meningitis.
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