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  • Title: Influence of third-generation cephalosporins on aerobic intestinal flora.
    Author: Guggenbichler JP, Kofler J.
    Journal: J Antimicrob Chemother; 1984 Sep; 14 Suppl B():67-70. PubMed ID: 6094464.
    Abstract:
    Excretion of an antibiotic in bile may result in high intra-intestinal concentrations and thus alteration in the faecal flora. We investigated the effects of cefoperazone (75% biliary excretion), ceftriaxone (45%) and cefotaxime (5%) on the aerobic faecal flora. Cefoperazone reduced numbers of normal Gram-negative bacilli and selected resistant Pseudomonas, Serratia and Klebsiella-Enterobacter. Ceftriaxone was similar. However, cefotaxime had little effect on the normal Gram-negative flora, and did not promote the emergence of resistant organisms.
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