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  • Title: Association of beta hydroxybutyric acidosis with isoniazid intoxication.
    Author: Pahl MV, Vaziri ND, Ness R, Nathan R, Maksy M.
    Journal: J Toxicol Clin Toxicol; 1984; 22(2):167-76. PubMed ID: 6094845.
    Abstract:
    Acute metabolic acidosis associated with accumulation of lactate has been previously reported in isoniazid (INH) intoxication. To our knowledge, association of INH toxicity with beta-hydroxybutyric acidosis has not been demonstrated previously. The present report documents the occurrence of beta-hydroxybutyric acidosis in patients with INH intoxication. The reason for the lack of previous reports of this association is not clear, although failure to measure plasma beta-hydroxybutyrate levels in previous studies is a likely possibility. Our patients received intravenous sodium bicarbonate, anticonvulsants and dialysis which resulted in complete reversal of metabolic acidosis and other manifestations of INH toxicity.
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