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  • Title: [Clinical evaluation of sulbactam/cefoperazone for infections in the field of obstetrics and gynecology].
    Author: Chimura T, Inoue K, Morisaki N.
    Journal: Jpn J Antibiot; 1984 Oct; 37(10):1928-33. PubMed ID: 6094871.
    Abstract:
    A daily dose of 2 or 4 grams of sulbactam/cefoperazone (SBT/CPZ) by drip infusion was given to 12 patients with gyneco-obstetrical infections and the results were following: The clinical effect was judged excellent in 2 cases, good in 9 cases and poor in 1 case, and the effective rate was 91.7%. Except for Streptococcus faecalis, the bacteriological effect was sufficient. A good effect was also seen in Pseudomonas cepacia resistant organism to other cephem antibiotics. Diarrhea was observed in 1 patient, and increases of GOT and GPT, possibly attributable to concomitantly used anticancer agent, were detected in another patient. In conclusion, SBT/CPZ with a 91.7% of efficacy rate, was useful in infections caused by beta-lactamase producing organisms and, thus, a useful agent for gyneco-obstetrical infections. A daily dose of 2 or 4 grams of sulbactam/cefoperazone (SBT/CPZ) by drip infusion was given to 12 patients with gynecological infections and the results were as follows. The clinical effect was judged excellent in 2 cases, good in 9 cases, and poor in 1 case and the effectiveness rate was 91.7%. Except for Streptococcus faecalis, the bacteriological effect was sufficient. A good effect was also seen in Pseudomonas cepacia organism resistant to other cephem antibiotics. Diarrhea was observed in 1 patient, and increases in GOT and GPT, possibly attributable to concomitantly used anticancer agents, were detected in another patient. In conclusion, SBT/CPZ with a 91.7% efficacy rate was useful in infections caused by beta-lactamas producing organisms and, thus, a useful agent for gnecological infections. (author's modified)
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