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Title: Polyoma virus DNA replication requires an enhancer. Author: de Villiers J, Schaffner W, Tyndall C, Lupton S, Kamen R. Journal: Nature; ; 312(5991):242-6. PubMed ID: 6095089. Abstract: Sequences which activate polyoma virus DNA replication are located within a region that also includes the transcriptional enhancer. We demonstrate a cis involvement of enhancers in DNA replication by showing that this region can be replaced by other enhancers, in a position- and orientation-independent manner, and that an immunoglobulin gene enhancer confers tissue-specific replicatory ability.[Abstract] [Full Text] [Related] [New Search]