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  • Title: Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells.
    Author: Reth MG, Alt FW.
    Journal: Nature; ; 312(5993):418-23. PubMed ID: 6095102.
    Abstract:
    It has been found that most immunoglobulin heavy(H)-chain gene diversity (D) segments carry their own 5' transcriptional promoter element. Transcription of rearrangements which use heavy-chain D and joining (J) segments in B-lymphoid cells ultimately leads to the production of a Dmu messenger RNA which contains the DJH segments linked to the mu heavy-chain constant region. If the D is joined to the JH segment in the appropriate translational reading frame, this Dmu mRNA is translated to yield a short Dmu protein with a variable DJH N-terminus.
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