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  • Title: Effectiveness of cefotaxime in gram-negative meningitis.
    Author: LeFrock JL, Molavi A, Smith B, Black P, Rosenberg M, Rolston K, Brodner R, Chandrasekar P, Henao L, Kannangara DW.
    Journal: Neurosurgery; 1984 Nov; 15(5):679-82. PubMed ID: 6095133.
    Abstract:
    We treated 12 adult patients who had gram-negative bacillary meningitis with cefotaxime administered intravenously at a dose of 2 g every 4 hours. The etiological organisms included Haemophilus influenzae (3 cases), Serratia marcescens (3 cases), Klebsiella pneumoniae (3 cases), Escherichia coli (2 cases), and Enterobacter (1 case). The infection followed a neurosurgical procedure in 6 cases. The mean inhibitory and bactericidal concentrations of cefotaxime for the isolates ranged from 0.125 to 0.25 microgram/ml. The cerebrospinal fluid (CSF) concentrations of cefotaxime ranged from 5.0 to 15.2 micrograms/ml, and the CSF bactericidal titers were 1:64 to 1:128. The CSF in all patients was sterilized within 96 hours. All 12 patients recovered, and there were no relapses.
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