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  • Title: Localization and levels of cyclic AMP during development of Dictyostelium discoideum.
    Author: Merkle RK, Cooper KK, Rutherford CL.
    Journal: Cell Differ; 1984 Oct; 14(4):257-66. PubMed ID: 6096023.
    Abstract:
    Cyclic AMP functions as the chemotactic signal during aggregation of amoebae of the cellular slime mold Dictyostelium discoideum. Evidence suggests that cAMP also acts as a regulatory molecule during Dictyostelium multicellular differentiation. We have used ultramicrotechniques and a sensitive radioimmunoassay to measure the levels of cAMP within the culmination stage individual. We show that there is a peak of cAMP at the culmination stage of development and that in the individual at this stage the molecule is localized in a gradient within the spore mass.
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