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  • Title: Monoclonal IgM with anti-muscle tissue activity in a patient with Waldenström's macroglobulinaemia: secretion of identical immunoglobulin by the established lymphoid cell line.
    Author: Micouin C, Seigneurin JM, Renversez JC, Roussel B, Favre M, Leroux D.
    Journal: Clin Exp Immunol; 1984 Dec; 58(3):677-84. PubMed ID: 6096055.
    Abstract:
    The monoclonal IgM kappa protein from a patient with Waldenström's macroglobulinaemia displayed antibody like activity against muscle and alpha-actinin. An Epstein-Barr virus associated lymphoid cell line, spontaneously established from blood lymphocytes, has been continuously secreting an immunoglobulin of the same isotype, isoelectric focusing spectrotype and reactivity; the cell line is probably leukaemic in origin since all cells display the translocation t (1; 19) and are aneuploid. We suggest these two monoclonal immunoglobulins have a common malignant origin.
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