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  • Title: The neural substrates of apomorphine-stimulated locomotor activity following denervation of the nucleus accumbens.
    Author: Swerdlow NR, Koob GF.
    Journal: Life Sci; 1984 Dec 17; 35(25):2537-44. PubMed ID: 6096659.
    Abstract:
    Efferent fibers from the nucleus accumbens (N.Acc.) to the substantia innominata and lateral preoptic region (SI/LPO) are believed to be essential for the supersensitive locomotor response to apomorphine in rats following 60HDA-induced denervation of the N.Acc., since destruction of cells within the SI/LPO eliminates this supersensitive response. In the present study, the neurochemical properties of this efferent projection were investigated. Injection of muscimol, a GABA agonist, directly into the SI/LPO produced a dose-dependent decrease in supersensitive locomotor activity at doses that did not alter baseline locomotion. Higher doses of muscimol actually produced a prolonged locomotor activation in all animals. These results suggest that the locomotor activation following stimulation of supersensitive dopamine receptors within the N.Acc. may involve a decrease in GABAergic activity at the level of the SI/LPO.
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