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  • Title: Sex differences in the cyclic adenosine 3':5'-monophosphate and growth hormone response to growth hormone-releasing factor in vitro.
    Author: Cronin MJ, Rogol AD.
    Journal: Biol Reprod; 1984 Dec; 31(5):984-8. PubMed ID: 6097316.
    Abstract:
    Human pancreas tumor growth hormone-releasing factor (hpGRF) induced more cellular cyclic adenosine 3':5'-monophosphate (AMP) accumulation and growth hormone release from male than female rat anterior pituitaries in vitro. This was reflected in a change in maximal levels achieved (efficacy) rather than potency, and was not an exclusive effect of hpGRF peptide; prostaglandin E2 also exhibited these effects. These data suggest that the origin of the larger spontaneous peak growth hormone levels in male rats may be within the anterior pituitary gland.
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