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  • Title: [Role of central alpha-adrenoreceptors in the mechanism of the hyperthermic action of prostaglandin E2].
    Author: Gurin VN, Vismont FI, Tsariuk VV.
    Journal: Farmakol Toksikol; 1984; 47(6):29-32. PubMed ID: 6097474.
    Abstract:
    It has been demonstrated in rat experiments that the central action of PGE2 results in body temperature rise associated with a reduction in the functional activity of hypothalamic adrenergic systems. In contrast to PGE2 and the beta-adrenomimetic isoproterenol, the alpha-adrenomimetics noradrenaline, mezaton and clonidine were shown to lower body temperature. In the rabbit, clonidine and PGE2 were found to have opposing effects on the neuronal activity of the anterior hypothalamus.
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