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  • Title: Barium-induced blockade of the inward rectifier in calf Purkinje fibres.
    Author: DiFrancesco D, Ferroni A, Visentin S.
    Journal: Pflugers Arch; 1984 Dec; 402(4):446-53. PubMed ID: 6097875.
    Abstract:
    The Ba-induced blockade of iK1 in calf Purkinje fibres was studied in the low concentration range (3-1,000 microM). The results showed that the blockade induced by hyperpolarizations was time-dependent, and that the rate of blockade increased with the Ba concentration and the negative pulse amplitude. At Ba concentrations higher than 1 mM the time course of iK1 blockade was not separable from the capacity transient. At these concentrations, and in a limited voltage range, the Ba-sensitive instantaneous current displayed a marked inward rectification and behaved with external K as expected for a pure K+ current, suggesting that under these conditions the only current affected by Ba was iK1. The Ba-sensitive current deceased with time during hyperpolarizations even when high external K was present, indicating that a voltage-dependent inactivation process could be at least in part responsible for the observed current decline.
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