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  • Title: [Circulating inhibitor of the Na+-K+ pump in essential hypertension. Physiological and pharmacological variations].
    Author: Pernollet MG, de Thé H, Delva P, Wauquier I, Devynck MA, Baudouin-Legros M, Deray G, Rosenfeld J, Meyer P.
    Journal: Arch Mal Coeur Vaiss; 1984 Oct; 77(11):1283-7. PubMed ID: 6098238.
    Abstract:
    The presence of a circulating Na+ pump inhibitor has been assessed in 112 subjects by studying the effects of deproteinized plasma on ouabain binding to erythrocytes and/or inhibition of Na+-K+-ATPase activity. High levels of an inhibitor possessing some digitalis-like properties, were associated with essential hypertension, hypertensive heredity, treatment of hypertension with beta-blocking agents and high sodium intake. Low levels were found in hypertensives on diuretics, patients with chronic renal failure and normotensive controls. These observations are consistent with a possible role of this circulating inhibitor in the control of sodium balance and in hypertension.
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