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  • Title: alpha 2 and alpha 1-Adrenoceptors mediate opposing actions on parasympathetic neurons.
    Author: Nakamura T, Yoshimura M, Shinnick-Gallagher P, Gallagher JP, Akasu T.
    Journal: Brain Res; 1984 Dec 10; 323(2):349-53. PubMed ID: 6098344.
    Abstract:
    We used intracellular recording methods to analyze the membrane responses to norepinephrine in cat vesical parasympathetic ganglia. In parasympathetic neurons, norepinephrine (NE) produces a membrane hyperpolarization, a membrane depolarization often accompanied by cell firing and a biphasic potential, a hyperpolarization followed by a depolarization. We found that the NE hyperpolarization is mediated through alpha 2-adrenoceptors while the NE depolarization is mediated through alpha 1-adrenoceptors. This situation is different than in sympathetic neurons where beta-adrenoceptors mediate a NE depolarization.
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